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  <xs:element id="legn_OtherPayablesAndAccrualsCurrent" abstract="false" name="OtherPayablesAndAccrualsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_IncreaseDecreaseThroughReclassificationOfVestedRestrictedStockEquity" abstract="false" name="IncreaseDecreaseThroughReclassificationOfVestedRestrictedStockEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_AdjustmentsForInventoryReserveProvision" abstract="false" name="AdjustmentsForInventoryReserveProvision" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_AdjustmentsForDepreciationOfRightOfUseAssets" abstract="false" name="AdjustmentsForDepreciationOfRightOfUseAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_AdjustmentsForDecreaseIncreaseInPrepaymentsOtherReceivableOtherAssets" abstract="false" name="AdjustmentsForDecreaseIncreaseInPrepaymentsOtherReceivableOtherAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_AdjustmentsForIncreaseDecreaseInOtherAssetsAndLiabilitiesNet" abstract="false" name="AdjustmentsForIncreaseDecreaseInOtherAssetsAndLiabilitiesNet" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_PrepaymentToCollaboratorForCollaborationRightOfUseAssets" abstract="false" name="PrepaymentToCollaboratorForCollaborationRightOfUseAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_AdditionInTimeDeposits" abstract="false" name="AdditionInTimeDeposits" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_DecreaseInTimeDeposits" abstract="false" name="DecreaseInTimeDeposits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_TimesDepositsCurrentAndNoncurrent" abstract="false" name="TimesDepositsCurrentAndNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_CashAndCashEquivalentsAsStatedInStatementOfFinancialPosition" abstract="false" name="CashAndCashEquivalentsAsStatedInStatementOfFinancialPosition" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_SupplementalCashFlowInformationAbstract" abstract="true" name="SupplementalCashFlowInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_NonCashRepaymentOfCollaborationInterestBearingAdvancedFunding" abstract="false" name="NonCashRepaymentOfCollaborationInterestBearingAdvancedFunding" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_DisclosureOfNotesAndOtherExplanatoryInformationExplanatory" abstract="false" name="DisclosureOfNotesAndOtherExplanatoryInformationExplanatory" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_BasisOfPreparationAbstract" abstract="true" name="BasisOfPreparationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_DisclosureOfOtherIncomeAndExpenseAbstract" abstract="true" name="DisclosureOfOtherIncomeAndExpenseAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_DisclosureOfOtherIncomeExpenseNetTextBlock" abstract="false" name="DisclosureOfOtherIncomeExpenseNetTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_LeaseAbstract" abstract="true" name="LeaseAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_DisclosureOfPrepaymentsOtherReceivablesAndOtherAssetsAbstract" abstract="true" name="DisclosureOfPrepaymentsOtherReceivablesAndOtherAssetsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_DisclosureOfPrepaymentsOtherReceivablesAndOtherAssetsExplanatoryTextBlock" abstract="false" name="DisclosureOfPrepaymentsOtherReceivablesAndOtherAssetsExplanatoryTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_DisclosureOfTimingOfTransferOfGoodsOrServicesTableTextBlock" abstract="false" name="DisclosureOfTimingOfTransferOfGoodsOrServicesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_DisclosureOfDetailedInformationAboutOtherIncomeExpenseTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutOtherIncomeExpenseTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_LesseeLeaseLiabilitiesTextBlock" abstract="false" name="LesseeLeaseLiabilitiesTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_DisclosureOfDetailedInformationAboutInventoriesExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutInventoriesExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_DisclosureOfDetailedInformationAboutPrepaymentsOtherReceivablesAndOtherAssetsExplanatoryTableTextBlock" abstract="false" name="DisclosureOfDetailedInformationAboutPrepaymentsOtherReceivablesAndOtherAssetsExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_DisclosureOfMovementsInCompanyShareCapitalAndSharePremiumExplanatoryTableTextBlock" abstract="false" name="DisclosureOfMovementsInCompanyShareCapitalAndSharePremiumExplanatoryTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="legn_NovartisMember" abstract="true" name="NovartisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="legn_RelatedPartySublicenseMember" abstract="true" name="RelatedPartySublicenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="legn_RevenueFromLicensingOfIntellectualProperty" abstract="false" name="RevenueFromLicensingOfIntellectualProperty" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_OutsideTheUnitedStatesOfAmericaMember" abstract="true" name="OutsideTheUnitedStatesOfAmericaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="legn_OtherMiscellaneousIncomeExpense" abstract="false" name="OtherMiscellaneousIncomeExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_LeasesTable" abstract="true" name="LeasesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="legn_JanssenMember" abstract="true" name="JanssenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="legn_LeasesLineItems" abstract="true" name="LeasesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_LesseeLeasingArrangementsLeasesTerm" abstract="false" name="LesseeLeasingArrangementsLeasesTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="legn_OngoingLeasePaymentsUnderTheLandLease" abstract="false" name="OngoingLeasePaymentsUnderTheLandLease" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_LeaseCommitmentPercentageOfFutureLeasePaymentsExpectedUnderProfitSharingAgreement" abstract="false" name="LeaseCommitmentPercentageOfFutureLeasePaymentsExpectedUnderProfitSharingAgreement" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="legn_IncreaseDecreaseThroughEffectOfExchangeRealignmentInForeignExchangeRate" abstract="false" name="IncreaseDecreaseThroughEffectOfExchangeRealignmentInForeignExchangeRate" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_DisclosureOfDetailedInformationAboutLeaseLiabilitiesTable" abstract="true" name="DisclosureOfDetailedInformationAboutLeaseLiabilitiesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="legn_DisclosureOfDetailedInformationAboutLeaseLiabilitiesLineItems" abstract="true" name="DisclosureOfDetailedInformationAboutLeaseLiabilitiesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_IncreaseInLeaseLiabilities" abstract="false" name="IncreaseInLeaseLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_IncreaseOfLeaseLiabilitiesBalance" abstract="false" name="IncreaseOfLeaseLiabilitiesBalance" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_InventoryReserve" abstract="false" name="InventoryReserve" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_DisclosureOfPrepaymentsOtherReceivablesAndOtherAssetsTable" abstract="true" name="DisclosureOfPrepaymentsOtherReceivablesAndOtherAssetsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="legn_PrepaymentsOtherReceivablesAndOtherAssetsMember" abstract="true" name="PrepaymentsOtherReceivablesAndOtherAssetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="legn_DisclosureOfPrepaymentsOtherReceivablesAndOtherAssetsLineItems" abstract="true" name="DisclosureOfPrepaymentsOtherReceivablesAndOtherAssetsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_OtherCollaborationReceivables" abstract="false" name="OtherCollaborationReceivables" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_PrepaymentsOtherReceivablesAndOtherAssets" abstract="false" name="PrepaymentsOtherReceivablesAndOtherAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_InterestBearingBorrowingsFundingAdvances" abstract="false" name="InterestBearingBorrowingsFundingAdvances" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_InterestBearingBorrowingsFundedInterestsAccrued" abstract="false" name="InterestBearingBorrowingsFundedInterestsAccrued" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_InterestBearingBorrowingsFundingAdvancesIncreaseDecrease" abstract="false" name="InterestBearingBorrowingsFundingAdvancesIncreaseDecrease" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_InterestBearingBorrowingsFundingAdvancesNetOfPreTaxProfitReceivable" abstract="false" name="InterestBearingBorrowingsFundingAdvancesNetOfPreTaxProfitReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_AuthorisedAbstract" abstract="true" name="AuthorisedAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_AuthorizedShareCapital" abstract="false" name="AuthorizedShareCapital" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_ShareCapitalMember" abstract="true" name="ShareCapitalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="legn_ShareCapitalRollForward" abstract="true" name="ShareCapitalRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="legn_ShareCapitalAndSharePremiumNumberOfSharesInIssue" abstract="false" name="ShareCapitalAndSharePremiumNumberOfSharesInIssue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="legn_ShareCapitalAndSharePremium" abstract="false" name="ShareCapitalAndSharePremium" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_ExerciseOfShareOptionNumberOfSharesInIssue" abstract="false" name="ExerciseOfShareOptionNumberOfSharesInIssue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="legn_ExerciseOfShareOption" abstract="false" name="ExerciseOfShareOption" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_ReclassificationOfVestedRestrictedStockUnitsNumberOfSharesInIssue" abstract="false" name="ReclassificationOfVestedRestrictedStockUnitsNumberOfSharesInIssue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="legn_ReclassificationOfVestedRestrictedStockUnitsShareCapitalAndSharePremium" abstract="false" name="ReclassificationOfVestedRestrictedStockUnitsShareCapitalAndSharePremium" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="legn_RevenueMilestonePaymentMember" abstract="true" name="RevenueMilestonePaymentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="legn_NumberOfCountriesToReceiveCommericalApproval" abstract="false" name="NumberOfCountriesToReceiveCommericalApproval" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="legn_ProceedsFromMilestonePayments" abstract="false" name="ProceedsFromMilestonePayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
